MDMB-FUBINACA (also known as MDMB(N)-Bz-F and FUB-MDMB) is an indazole-based synthetic cannabinoid that is a potent agonist for the cannabinoid receptors, with Ki values of 1.14 nM at CB1 and 0.1228 nM at CB2 and EC50 values of 0.2668 nM at CB1 and 0.1411 nM at CB2, and has been sold online as a designer drug. Its benzyl analogue (instead of 4-fluorobenzyl) has been reported to be a potent agonist for the CB1 receptor (Ki = 0.14 nM, EC50 = 2.42 nM). The structure of MDMB-FUBINACA contains the amino acid 3-methylvaline or tert-leucine methyl ester.
Synthetic cannabinoids are a class of molecules that bind to the same receptors to which cannabinoids in cannabis plants THC and CBD attach. They are designer drugs, commonly sprayed onto plant matter and are usually smoked, although they have also been ingested as a concentrated liquid form in the US and UK. They have been marketed as herbal incense, or “herbal smoking blends”, and sold under common names like K2, Spice, and Synthetic Marijuana. They are often labeled “not for human consumption” for liability defense. A large and complex variety of synthetic cannabinoids are designed in an attempt to avoid legal restrictions on cannabis, making synthetic cannabinoids designer drugs.
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